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Insulin glargine

What is insulin glargine?

Insulin glargine is a long-acting insulin used to treat type 1 and type 2 diabetes in certain patients to improve and maintain blood glucose levels. Insulin glargine is a man-made form of human insulin that is used once daily to provide a base level of insulin that keeps working for 24 hours or longer.

Insulin glargine is available under the brand names LantusBasaglarToujeo, Semglee, and Rezvoglar.

Rezvoglar, Lantus, Semglee, and Toujeo are FDA-approved to be used for use in adult and pediatric patients with type 1 and type 2 diabetes. Basasglar is FDA-approved to be used by adults for type 2 diabetes and also for adults and pediatric patients with type 1 diabetes. In patients with type 1 diabetes, insulin glargine must be used together with a short-acting insulin.

Insulin glargine side effects

Common insulin glargine side effects may include low blood sugar, swelling, weight gain, allergic reaction, itching, rash, or thickening or hollowing of the skin where you injected the medicine (lipodystrophy).

Serious insulin glargine side effects

Get emergency medical help if you have signs of insulin allergy: redness or swelling where an injection was given, itchy skin rash over the entire body, trouble breathing, fast heartbeats, feeling like you might pass out, or swelling in your tongue or throat.

Insulin glargine may cause other serious side effects. Call your doctor at once if you have:

  • rapid weight gain, swelling in your feet or ankles;
  • shortness of breath; or
  • low blood potassium–leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling.

Before taking this medicine

You should not use insulin glargine if you are allergic to insulin, or if you are having an episode of hypoglycemia (low blood sugar) or diabetic ketoacidosis (call your doctor for treatment).

Different brands of insulin glargine are specifically approved for different age groups and different diabetes types. The safety and effectiveness of insulin glargine in pediatric patients younger than 6 years of age with type 1 diabetes and pediatric patients with type 2 diabetes has not been established.

Tell your doctor if you have ever had:

  • liver or kidney disease; or
  • heart failure or other heart problems.

Tell your doctor if you also take pioglitazone or rosiglitazone (sometimes contained in combinations with glimepiride or metformin). Taking certain oral diabetes medicines while you are using insulin may increase your risk of serious heart problems.

Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant, as it is not known if insulin glargine will harm your unborn baby. Follow your doctor’s instructions about using this medicine if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy.

Breastfeeding

Tell your healthcare provider if you are breastfeeding or are planning to breastfeed, as it is not known if insulin glargine may harm your breastfeeding baby.

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